Lily Tomlin

Ms. Frizzle (voice)

Max Beckford

Tim (voice)

Daniel DeSanto

Carlos (voice)

Stuart Stone

Ralphie (voice)

Erica Luttrell

Keesha (voice)

Lisa Yamanaka

Wanda (voice)

Tara Meyer

Dorothy Ann (voice)

Maia Filar

Phoebe (voice)

Malcolm-Jamal Warner

The Producer (voice)

Amos Crawley

Arnold (voice)

Carol Channing

Cornelia C. Contralto II (voice)

Elliott Gould

Mr. Perlstein (voice)

Dana Elcar

Mr. Terese (voice)

Dom DeLuise

Baker (voice)

Sherman Hemsley

Mr. Junkett (voice)

Ed Asner

Gen. Aranius (voice)

Alex Trebek

Announcer (voice)

Tyne Daly

Ralphie's Mom (voice)

Michael York

Harry Herpst (voice)

Eartha Kitt

Mrs. Franklin (voice)

Edward James Olmos

Mr. Ramon (voice)

Robby Benson

Archibald Seedplot (voice)

Ed Begley Jr.

Logaway Larry (voice)

Matt Frewer

Inspector 47 (voice)

Jessica Walter

Ashlee Walker Club Dupree (voice)

Dolly Parton

Katrina Eloise 'Murph' Murphy (voice)

Wynonna Judd

Molly Cule (voice)

Paul Winfield

Mr. Ruhle (voice)

Dabney Coleman

Horace Scope (voice)

Bebe Neuwirth

Flora Whiff (voice)

Malcolm McDowell

Mr. McClean (voice)

Dan Marino

Garth Sinew (voice)

Cindy Williams

Gerri Poveri (voice)

Rita Moreno

Dr. Carmina Skeledon (voice)

Tony Randall

Radius Ulna 'R.U.' Humerus (voice)

Rosalind Chao

Mrs. Li (voice)

Renessa Blitz

Caller (voice)

Cindy McGee

Ghostly Call-Taker (voice)

Jacelyn Holmes

Caller (voice)

Chantellese Kent

Caller (voice)

Dominic Zamprogna

Caller (voice)

Katie Coristine

Caller (voice)

Gene Mack

Father (voice)

John White

Caller (voice)

Michael Barry

Caller (voice)

Steve Schnier

Photographer (voice)

Alissa Berg

Caller (voice)

Byron Abalos

Caller (voice)

Jamie Leigh Rainey

Caller (voice)

Kevin Zegers

Caller (voice)

Annick Obonsawin

Caller (voice)

Robin Weekes

Caller (voice)

Susan Blu

Baby (voice)

Shannon Duff

Caller (voice)

Swoosie Kurtz

Dorothy Ann's Mom (voice)

Doron Bell

Boy / Man / Mascot (voice)

Jonathan Schwartz

Caller (voice)

Sarena Paton

Caller (voice)

Gary Krawford

Tow Truck Driver (voice)

Dov Tiefenbach

Caller (voice)

Elizabeth Hanna

Judge (voice)

Christopher Bell

Caller (voice)

Michael Caloz

Caller (voice)

George Buza

Switch Operator (voice)

Britt McKillip

Caller (voice)

Sarah Ann Kennedy

Evan Rourke (voice)

Asia Vieira

Caller (voice)

Gil Filar

Caller (voice)

Neil Crone

Caller (voice)

Kate Rodriguez

Caller (voice)

Benjamin Plener

Caller (voice)

Jane Luk

Caller (voice)

Don Dickinson

Customer (voice)

Lance Paton

Caller (voice)

Ashley Taylor

Caller (voice)

Ashley Brown

Caller (voice)