Frank Welker

Fred Jones / Scooby-Doo (voice)

Casey Kasem

Shaggy Rogers (voice)

Mindy Cohn

Velma Dinkley (voice)

Grey DeLisle

Daphne Blake (voice)

Lindsay Pagano

Self (voice)

Kath Soucie

Susan Dinwiddie (voice)

Brian Unger

Avalanche Anderson (voice)

Héctor Elizondo

Dr. Gutierrez (voice)

Dave Foley

Laslow Oswald (voice)

Bumper Robinson

Cap N' Robbie / Native Bearer (voice)

Larc Spies

Andy Dinwiddie (voice)

Jesse Borrego

Luis Cepeda (voice)

Kerrigan Mahan

Del Stone (voice)

Rip Taylor

Mr. Wackypants (voice)

Jason Harris

Flapjack / Announcer (voice)

Josh Peck

Damian / Kid / Zombie Kid #2 (voice)

Chris Klug

Self (voice)

Mimi Rogers

Maura Ravenmane / Helga (voice)

Daryl Sabara

Tommy / Steve (voice)

Matt Levin

Ticket Taker / Matt (voice)

David Faustino

Curt Crunch (voice)

Lauren Tom

Nancy Chang (voice)

Eddie Deezen

Gibby Norton (voice)

Laraine Newman

Wor-El (voice)

Corey Burton

Gusano Grande (voice)

Jess Harnell

Lute Player / Shane Flinty / Constable (voice)

Jim Cummings

Broderick Bosepheus / Humongus Hammer (voice)

John DiMaggio

Mike Fury (voice)

Tasia Valenza

Brooke Bjork (voice)

Beng Spies

Murph / Randy Dinwiddie (voice)

Brian Tochi

J.J. Hakimoto (voice)

Irene Bedard

Cody Long (voice)

Michael Horse

Leon Strongfeather (voice)

Pamela Adlon

Chris / Eddie (voice)

Phil LaMarr

Toddy Stickfigger / Cabbie (voice)

Billy West

Jimmy Proudwolf (voice)

Roger Rose

Sparrow Man / P.A. Announcer (voice)

Vanessa Marshall

Danica LeBlake (voice)

Carlos Alazraqui

Roberto Torres / Jaime Herrera / Motor Cross Guy #1 (voice)

Jim Belushi

Asa Buckwald (voice)

Kathy Kinney

Sheriff Ellen Perkins (voice)

Peter Scolari

Professor Higginson (voice)

M. Emmet Walsh

Jeb (voice)

Teri Garr

Sandy Gordon (voice)

Bill Mumy

Harry Noze (voice)

Mark Hamill

Tommy's Father (voice)

Eddie Santiago

Chip Hernandez, Jr. (voice)

Gedde Watanabe

Vincent Wong (voice)

Taylor Lautner

Ned (voice)

Kathy Griffin

Autumn Summerfield (voice)

Kevin Michael Richardson

Sharky Tazo / Stink Eye (voice) · Lloyd Mbuku / Safari Member / Henry Huncecker (voice)

Rachael MacFarlane

Sheila (voice)

James Arnold Taylor

Dr. Laslow Ostwald / Tad (voice)

Mike Piazza

Self (voice)

Clyde Kusatsu

Dr. Akira Onodera / Fisherman / Desk Clerk (voice)

Mako

The Ancient One (voice)

Daran Norris

Ugo DiRinaldi / Shopkeeper (voice)

Kimberly Brooks

Phylidia Flanders / Backup Singer #2 (voice)

Nick Jameson

Lysander Demas / Scary Looking Man (voice)

Gwendoline Yeo

Lt. Keiko Tanaka (voice)

Tara Strong

Terry / Joe (voice)

Rino Romano

Coral Creature (voice)

Colleen O'Shaughnessey

Jingle (voice)

Kevin McDonald

Julian Libris (voice)

Benito Martinez

Horatio Hidalgo (voice)

Jonathan Osser

Billy Blather (voice)

Frankie Ryan Manríquez

Jimmy (voice)

Jennifer Hale

Thorn (voice)

Fred Tatasciore

Clyde / Toxic Terror (voice)

Diedrich Bader

Uncle Evan (voice)

Jenny McCarthy

Marcy (voice)

Rhea Perlman

Agnes (voice)

Tom Kenny

Band Member / Curtis / Fair Headed Boy (voice)

Paul Stanley

Self (voice)

John Stephenson

Zelig (voice)

Julia Sweeney

Aunt Meg (voice)

Rob Paulsen

Jamison Steven Ripley / Pan Lute Player / Puny Guy (voice)

Steve Blum

Melbourne O’Reilly (voice)

Dee Bradley Baker

Fish Fiend (voice)

DeeDee Rescher

Sylvie (voice)

Ben Diskin

Benji / Travis / Zombie Kid #1 (voice)

Chuck Comeau

Self (voice)

Dan Castellaneta

Officer McBride / Police Officer (voice)

David Desrosiers

Self (voice)

Denzel Whitaker

Jake / Kid (voice)

Eva Almos

Captain Corvina Cloyd (voice)

Greg Ellis

Detective Kang (voice)

Harland Williams

George (voice)

James Horan

Dr. Fleg / Bandit (voice)

James Sie

Louie Hong Fa (voice)

Jane Wiedlin

Backup Singer #1

JC Chasez

Self (voice)

Jeff Bennett

Charles 'Crunchy' Granville / Fritz / Mr. Keenan (voice)

Jeff Stinco

Self (voice)

Jill Talley

Frida Flora (voice)

Joey Lauren Adams

Rachel (voice)

John Gabriel

Dr. Zola / Worker (voice)

John O'Hurley

Beavis Bottomczek (voice)

Kathy Nagler

Sergeant Linda Rauch (voice)

Khary Payton

Mitch (voice)

Larry Drake

Moss T. Meister / Burglar #2 / Scooby Snax Monster (voice)

Maurice LaMarche

Haze Ferlenguini / Security Guy (voice)

Michael Gough

Vampire (voice)

Mikey Kelley

Monroe Hopper (voice)

Miranda Cosgrove

Miranda Wright / Stacy (voice)

Moira Quirk

Susie Smythe (voice)

Nika Futterman

Rutie Banez (voice)

Pat Fraley

Acteur

Paul Julian

Road Runner (voice) (archive footage) (uncredited)

Rodger Bumpass

Announcer / Steve (voice)

Ron Perlman

Inspector Malpumpkin / Joe / Frozen Fiend (voice)

Ryan Sheckler

Self (voice)

Sébastien Lefebvre

Self (voice)

Stacie Chan

Alex (voice)

Stacy Keach

The Mayor (voice)

Susanne Blakeslee

Penelope Bailey (voice)

Tara Lipinski

Grey (voice)

Vince Corazza

Zeke Zillion (voice)

William Schallert

Professor Pomfrit (voice)