Jim Cummings

Cat (voice)

Tom Kenny

Dog / Cliff (voice)

Carlos Alazraqui

Winslow / Lube (voice)

Maria Bamford

Shriek (voice)

Billy West

Rancid Rabbit / Mr. Sunshine (voice)

John Kassir

Dunglap / Mervis (voice)

Peter Hannan

Pete the Polecat (voice)

Laraine Newman

Ingrid Twins / Boy in Crowd (voice) · Ingrid Twins (voice)

Greg Burson

Barry the Baboon (voice)

Rodger Bumpass

Pig / Man (voice)

Dave Thomas

Mailman (voice) · Mean Bob (voice)

Jane Krakowski

CatDog's Mother (voice)

Billy Bob Thornton

CatDog's Father (voice)

April Winchell

Space Grannies (voice)

Julianne Buescher

Catrina (voice)

Rob Paulsen

Heinz / Frank (voice) · Stanky (voice)

Andrea Martin

Talluhla / Indian (voice)

Debi Derryberry

Greaser Baby Girl (voice)

Gail Matthius

Feline (voice)

Tom Kane

Evil Eric (voice)

Joe Liss

Dan (voice)

Kath Soucie

Lorraine (voice)

Edie McClurg

Mrs. Grock (voice)

Kathy Kinney

Brat (voice)

Peter MacNicol

Runt (voice)

Teresa Parente

Maria Cowess / Mrs. Banks (voice)

Cole Hannan

Cat Fanatic (voice)

Ruby Hannan

Cat Fanatic (voice)

Dwight Schultz

Eddie the Squirrel / Tick (voice)

Nika Futterman

Lola (voice) · Lola / Lady #1 (voice)

Brian Doyle-Murray

Santa Claus (voice)