Patton Oswalt

George Tarleton / M.O.D.O.K. (voice)

Melissa Fumero

Melissa Tarleton (voice)

Aimee Garcia

Jodie Ramirez-Tarleton (voice)

Ben Schwartz

Louis 'Lou' Tarleton (voice)

Wendi McLendon-Covey

Monica Rappaccini / Scientist Supreme (voice)

Beck Bennett

Austin Van Der Sleet (voice)

Jon Daly

Super-Adaptoid (voice)

Sam Richardson

Gary Garoldson (voice)

Jon Hamm

Tony Stark / Iron Man (voice)

Zara Mizrahi

Carmilla Rappaccini (voice)

Nathan Fillion

Simon Williams / Wonder Man (voice)

Whoopi Goldberg

Marian Pouncy / Poundcakes (voice)

Chris Parnell

Alvin Healy / Tenpin (voice)

Eddie Pepitone

Bruno Horgan / Melter (voice)

John DiMaggio

Rodney (voice) · A.I.M. agent (voice)

Meredith Salenger

Brandi (voice) · Whitney Frost / Madame Masque / Club Supervisor (voice)

Brian Posehn

General Dagger (voice)

Lennon Parham

Doris / Mrs. Horgan (voice)

Alan Tudyk

Arcade (voice)

Kevin Michael Richardson

David Cannon / Whirlwind (voice)

Dustin Ybarra

Antonio Rodriguez / Armadillo (voice)