Andree Maranda

Sara

Mitch Cohen

The Toxic Avenger

Jennifer Prichard

Wanda

Cindy Manion

Julie

Robert Prichard

Slug

Gary Schneider

Bozo

Pat Ryan

Mayor Belgoody

Mark Torgl

Melvin

Dick Martinsen

Officer O'Clancy

Chris Liano

Walter Harris

David Weiss

Chief of Police

Dan Snow

Cigar Face

Doug Isbecque

Knuckles

Charles Lee Jr.

Nipples

Patrick Kilpatrick

Leroy

Larry Sulton

Frank

Michael Russo

Rico

Norma Pratt

Mrs. Haskell

Andrew Craig

Fred

Ryan Sexton

Johnny

Sarabel Levinson

Melvin's Mom

Al Pia

Tom Wrightson

Reuben Guss

Dr. Snodburger

Kenneth Kessler

Toxic Avenger's Voice (voice)

Barbara Gurskey

Barbie

Rick Collins

Bully

Randy Schein

Bozo's Friend

Richard Duggan

Ice Cream Man

Donna Winter

Mayor's Secretary

Marisa Tomei

Health Club Girl (uncredited)

Roxanne Maranda

Girl in Restaurant