Rainn Wilson

Frank Darbo

Elliot Page

Libby

Liv Tyler

Sarah

Kevin Bacon

Jacques

Gregg Henry

Detective John Felkner

Michael Rooker

Abe

Andre Royo

Hamilton

Sean Gunn

Toby

Stephen Blackehart

Quill

Linda Cardellini

Pet Store Employee

Nathan Fillion

The Holy Avenger

Don Mac

Mr. Range

Gerardo Davila

Cop

Grant Goodman

Young Frank

Paul T. Taylor

Frank Sr.

Connor Day

Teenage Frank

James Gunn

Demonswill

Mikaela Hoover

Holly

Nick Holmes

Jim

Matt Moore

Jesus / Guy In Line

Rob Zombie

Voice Of God (voice)

Steve Agee

Comic Book Store Jerk

Laurel Whitsett

Librarian

James Lentzsch

Passenger Teen

Nate Rubin

Driving Teen

Edrick Browne

Nathaniel

Danny Cosmo

Purse-snatcher

Krystal Mayo

Wheelchair Woman

Russell Towery

Chickenhawk

Mario Jiminez Jr.

Chicken

Jonathan Winkler

Transvestite

Mollie Milligan

Sarah's Sister

Gerry May

Newscaster

Valentine Miele

Line Butter

Michelle Gunn

Line Butter's Girlfriend

Darcel White Moreno

Waitress

Greg Ingram

Long-haired Hood

Lindsay Soileau

Libby's Friend

Brandon Belknap

Christian

Zach Gilford

Jerry