Ralph Fiennes

Spider

Tobey Maguire

Spider-Man / Peter Parker

Miranda Richardson

Yvonne / Mrs. Cleg

Willem Dafoe

Green Goblin / Norman Osborn

Gabriel Byrne

Bill Cleg

Kirsten Dunst

Mary Jane Watson

James Franco

Harry Osborn

Lynn Redgrave

Mrs. Wilkinson

Cliff Robertson

Ben Parker

John Neville

Terrence

Philip Craig

John

Rosemary Harris

May Parker

Bradley Hall

Spider Boy

J.K. Simmons

J. Jonah Jameson

Gary Reineke

Freddy

Joe Manganiello

Flash Thompson

Gerry Becker

Maximilian Fargas

Sara Stockbridge

Gladys

Bill Nunn

Joseph 'Robbie' Robertson

Cliff Saunders

Bob

Jack Betts

Henry Balkan

Tara Ellis

Nora

Arthur Whybrow

Ernie

Stanley Anderson

General Slocum

Nicola Duffett

Barmaid

Ron Perkins

Dr. Mendel Stromm

Jake Nightingale

Large Man

Michael Papajohn

Carjacker

Donald Ewer

Toothless Jack

K.K. Dodds

Simkins

Joan Heney

Cook

Ted Raimi

Hoffman

Bruce Campbell

Ring Announcer

Peter Elliott

Resident

Alec Stockwell

Resident

Elizabeth Banks

Miss Brant

John Paxton

Houseman

Scott McCord

Resident

Rachel Taggart

Young Woman

Tim DeZarn

Philip Watson

Taylor Gilbert

Madeline Watson

Randy Poffo

Bone Saw McGraw

Larry Joshua

Wrestling Promoter

Timothy Patrick Quill

Wrestling Arena Guard

Lisa Danielle

Bone-ette

Natalie T. Yeo

Bone-ette

Erica D. Porter

Bone-ette

Kristen Davidson

Bone-ette

Jason Padgett

Flash's Crony

Shan Omar Huey

Teacher

Sally Levi

Girl on Bus

Evan Arnold

Doctor

Jill Sayre

Nurse

Jim Ward

Project Coordinator

David Holcomb

Test Pilot

Octavia Spencer

Check-In Girl

Brad Grunberg

Heckler

Shane Habberstad

Little Billy

Deborah Wakeham

Billy's Mom

Rachael Bruce

Times Square Child

Macy Gray

Macy Gray

Myk Watford

Cop at Fire

Bill Calvert

Fireman

Sylva Kelegian

Mother at Fire

Kristen Marie Holly

Young Lady at Fire

Ajay Mehta

Cabbie

Peter Appel

Cabbie

Scott Spiegel

Marine Cop

Matt Smith

Cop at Carjacking

Sara Ramirez

Cop at Carjacking

Lucy Lawless

Punk Rock Girl

Jayce Bartok

Subway Guitarist

Joseph D'Onofrio

Opinionated Cop

Jim Norton

Surly Truck Driver

Corey Mendell Parker

Chaperone in Tram

Ashley Edner

Girl in Tram

William Joseph Firth

Boy in Tram

Alex Black

Boy in Tram

Laura Gray

Tram Group Mother

Joe Virzi

New Yorker on Bridge

Michael Edward Thomas

New Yorker on Bridge

Robert Kerman

Tugboat Captain

Stan Lee

Man in Fair (uncredited)

Una Damon

Lab Tour Guide (uncredited)

Rick Avery

Cop (uncredited)

Peter Aylward

Colonel (uncredited)

Jillian Clare

Crying Girl in Tram (uncredited)

Chris Coppola

Kyle (uncredited)

Jesse Heiman

Spectator at School Fight (uncredited)

Benny Urquidez

Mugger (uncredited)

Scott L. Schwartz

Screaming Wrestler (uncredited)

Jophery C. Brown

Chef (uncredited)

Brian J. Williams

Young Thug #2 (uncredited)

Mark De Alessandro

Cop (uncredited)

Tia Dionne Hodge

Uptown Woman (uncredited)

Loren Janes

Board of Directors Member (uncredited)

Andray Johnson

Balkan's Aide (uncredited)

Martin Pfefferkorn

Thug on 8x10 (uncredited)

Sean Valla

Boat Light Man (uncredited)

Pete Macnamara

Pentagon Officer (uncredited)

Al Goto

Cop (uncredited)

Sam Raimi

Popcorn Thrower (uncredited)

Craig 'Radio Man' Castaldo

Man with Bike (uncredited)

Lou Torres

Enrique