Will Forte

Shaggy Rogers (voice)

Mark Wahlberg

Blue Falcon (voice)

Jason Isaacs

Dick Dastardly (voice)

Gina Rodriguez

Velma Dinkley (voice)

Zac Efron

Fred Jones (voice)

Amanda Seyfried

Daphne Blake (voice)

Kiersey Clemons

Dee Dee Skyes (voice)

Ken Jeong

Dynomutt (voice)

Tracy Morgan

Captain Caveman (voice)

Frank Welker

Scooby-Doo / Pterodactyl (voice)

Iain Armitage

Young Shaggy (voice)

Mckenna Grace

Young Daphne (voice)

Pierce Gagnon

Young Fred (voice)

Ariana Greenblatt

Young Velma (voice)

Simon Cowell

Simon Cowell (voice)

Christina Hendricks

Officer Jaffe (voice)

Henry Winkler

Keith (voice)

Harry Perry

Harry Perry (voice)

John DiMaggio

Restaurant Owner (voice)

Kevin Heffernan

Bike Cop Gary (voice)

Ira Glass

Ira Glass (voice)

Henry Kaufman

Chad / Chet (voice)

Maya Erskine

Judy Takamoto (voice)

Billy West

Muttley (voice)

Don Messick

Muttley (archive sound) (voice)

Fred Tatasciore

Cerberus (voice)

Justina Machado

Jamie Rivera (voice)

Kennedy Peil

Indira Knight (voice)

John McDaniel

Hal Murphy (voice)

Ryan Folsey

Beach Guy (voice)

Pam Coats

Mrs. Rogers (voice)

Tony Cervone

Ghost / Mr. Rigby / Alice (voice)

Adam Sztykiel

Officer Casey (voice)

Alex Kauffman

Officer North (voice)

Vanara Taing

Baby Rotten (voice)

Sarah Lancia

Dispatcher Stevens (voice)

Maven Morgan

Kari (voice)

Eric Cowell

Ben (voice)