Frank Welker

Scooby-Doo / Fred Jones (voice)

Mindy Cohn

Velma Dinkley (voice)

Grey DeLisle

Daphne Blake (voice)

Matthew Lillard

Shaggy Rogers (voice)

Obba Babatundé

Vampire Actor #4 (voice)

Jeff Bennett

Vincent Van Helsing / Valdronya (voice)

Julianne Buescher

Vampire Actor #3 / Reporter (voice)

Christian Campbell

Bram (voice)

Jim Cummings

Jesper Poubelle / Tulie (voice)

Rob Paulsen

Sheriff / Vampire Actor #2 / Teen Vampire (voice)

Mindy Sterling

Lita Rutland (voice)

Robert Townsend

Vampire Actor #1 (voice)

Jim Wise

Henry (voice)