Milla Jovovich

Alice

Sienna Guillory

Jill Valentine

Michelle Rodriguez

Rain

Aryana Engineer

Becky

Li Bingbing

Ada Wong

李冰冰

Boris Kodjoe

Luther West

Johann Urb

Leon S. Kennedy

Robin Kasyanov

Sergei

Kevin Durand

Barry Burton

Ofilio Portillo

Tony

Oded Fehr

Todd / Carlos

עודד פהר

Colin Salmon

One

Shawn Roberts

Albert Wesker

Toshio Oki

Japanese Policeman

Takato Yamashita

Japanese Businessman

中島美嘉

J Pop Girl

Megan Charpentier

The Red Queen

Ava Merson-O'Brien

The Red Queen (voice)

Ray Olubowale

The Axe Men

Kevin Shand

The Axe Men

Hiroo Minami

Tokyo Zombie (uncredited)