Eddie Murphy

Pluto Nash

Randy Quaid

Bruno

Rosario Dawson

Dina Lake

Joe Pantoliano

Mogan

Jay Mohr

Tony Francis

Luis Guzmán

Felix Laranga

James Rebhorn

Belcher

Peter Boyle

Rowland

Burt Young

Gino

Miguel A. Núñez Jr.

Miguel

Pam Grier

Flura Nash

John Cleese

James

Victor Varnado

Kelp

Illeana Douglas

Dr. Mona Zimmer

Jacynthe René

Babette

Alissa Kramer

Gina Francis

Heidi Kramer

Filomina Francis

Lillo Brancato

Larry

Alex Sol

Tommy

Doug Spinuzza

Doug

Andrée Fafard

Holographic Spokesmodel

Stu 'Large' Riley

Club Pluto Bouncer

Roc LaFortune

Jimmy

Russell Yuen

Oliver

Bill Corday

Roy

Angela Perzow

Robot Maid

Ezra Franklyn

Robot Thug

Don Jordan

Reporter

Lorca Simons

Pretty Reporter

Eric Hoziel

Johnson

Christopher Bregman

Michalak

Marlon Sterling Long

Lindsey (as Marlon Long)

Mary C. Hammett

Holographic Nurse

Serge Houde

FBI Agent

Jonathan Stark

Desk Clerk

Terry Haig

Security Guard

Roger E. Reid

Pit Boss

Michael Rudder

Croupier

Alex Bisping

Ted Jefferies (as Alexandre Bisping)

Cornelia Sharpe

Tony Francis Fan (as Cornelia Sharpe Bregman)

Mark Camacho

Robot Holding Cell Clerk

Alec Baldwin

M.Z.M

Linda E. Smith

Dr. Runa Pendanken (uncredited)

Audrey Wasilewski

Waitress (uncredited)