Morgan Freeman

Charlie

Renée Zellweger

Betty

Chris Rock

Wesley

Greg Kinnear

Dr. David Ravell

Aaron Eckhart

Del

Tia Texada

Rosa

Crispin Glover

Roy

Pruitt Taylor Vince

Ballard

Allison Janney

Lyla

Kathleen Wilhoite

Sue Ann

Elizabeth Mitchell

Chloe

Susan Barnes

Darlene

Harriet Sansom Harris

Ellen

Sung-Hi Lee

Jasmine

Laird Macintosh

Dr. Lonnie Walsh

Steven Gilborn

Blake

Jenny Gago

Mercedes

Sheila Kelley

Joyce

Matthew Cowles

Merle

Wayne Tippit

Doctor

George D. Wallace

Grandfather

Lesley Woods

Grandmother

Cynthia Martells

Chief Nurse

Alfonso Freeman

ER Doctor

Kevin Rahm

Friend #1

Steven Culp

Friend #2

Deborah May

Gloria Walsh

Max Murphy

Studio Guard

Tina Smith

Waitress

T.J. Kennedy

Cook

Irene Olga López

Rosa's Mother

Steve Franken

Administrator

Kelwin Hagen

Deputy

Josh Dotson

Parking Valet

Dona Hardy

Woman Patient

Paul Threlkeld

Grip

José Vásquez

Gang Member

Jack Jacobson

Stagehand

Elaine Corral Kendall

Anchor

Greg Bronson

Diner Patron (uncredited)