Emma Thompson

Nanny McPhee

Colin Firth

Mr. Brown

Kelly Macdonald

Evangeline

Thomas Brodie-Sangster

Simon

Eliza Bennett

Tora

Jennifer Rae Daykin

Lily

Raphaël Coleman

Eric

Samuel Honywood

Sebastian

Holly Gibbs

Christianna

Hebe Barnes

Baby Agatha

Zinnia Barnes

Baby Agatha

Angela Lansbury

Aunt Adelaide

Celia Imrie

Mrs. Quickly

Imelda Staunton

Mrs. Blatherwick

Elizabeth Berrington

Letita

Derek Jacobi

Mr. Wheen

Patrick Barlow

Mr. Jowls

Adam Godley

Vicar

Claire Downes

Nanny Whetstone

Phyllida Law

Mrs. Partridge (voice)

Freya Fumic

The Voice of Baby Agatha (voice)