Guy Pearce

Leonard

Carrie-Anne Moss

Natalie

Joe Pantoliano

Teddy

Mark Boone Junior

Burt

Russ Fega

Waiter

Jorja Fox

Leonard's Wife

Stephen Tobolowsky

Sammy

Harriet Sansom Harris

Mrs. Jankis

Thomas Lennon

Doctor

Callum Keith Rennie

Dodd

Kimberly Campbell

Blonde

Marianne Muellerleile

Tattooist

Larry Holden

Jimmy