Matthew McConaughey

Cooper

Anne Hathaway

Brand

Michael Caine

Professor Brand

Jessica Chastain

Murph

Casey Affleck

Tom

Wes Bentley

Doyle

Topher Grace

Getty

Mackenzie Foy

Murph (10 Yrs.)

Ellen Burstyn

Murph (older)

John Lithgow

Donald

Bill Irwin

TARS (voice)

David Gyasi

Romilly

Timothée Chalamet

Tom (15 Yrs.)

Matt Damon

Mann

Josh Stewart

CASE (voice)

Leah Cairns

Lois

Liam Dickinson

Coop

Francis X. McCarthy

Boots

William Devane

Williams

Andrew Borba

Smith

Elyes Gabel

Administrator

David Oyelowo

School Principal

Collette Wolfe

Ms. Hanley

Jeff Hephner

Doctor

Russ Fega

Crew Chief

Lena Georgas

Nurse Practitioner

Brooke Smith

Nurse

Flora Nolan

Girl on Truck

Griffen Fraser

Boy on Truck

Kristian Van der Heyden

Scientist (uncredited)

William Patrick Brown

NASA employee (uncredited)

Benjamin Hardy

NASA Scientist (uncredited)

Joseph Oliveira

Astronaut (uncredited)

Alexander Michael Helisek

Construction boss (uncredited)

Rory Nolan

Little Boy in the Hospital (uncredited)