Adrien Brody

Leonard Chess

Jeffrey Wright

Muddy Waters

Gabrielle Union

Geneva Wade

Columbus Short

Little Walter

Cedric the Entertainer

Willie Dixon

Emmanuelle Chriqui

Revetta Chess

Eamonn Walker

Howlin' Wolf

Tammy Blanchard

Isabelle Allen

Eric Bogosian

Alan Freed

Norman Reedus

Chess Engineer

Yasiin Bey

Chuck Berry

Beyoncé

Etta James

Josh Alscher

Mick Jagger

Tim Bellow

Man in the Caddy

Tony Bentley

Lomax

Marc Bonan

Keith Richards

Douglas Crosby

Policeman (Little Walter beating)

Dexter Darden

Geneva's Teenage Son

Veronika Dash

Blonde Girl

Sean Shyboy Davis

Toothless Hillbilly Little Walter

Eshaya Draper

Charles Waters

Christopher Durham

Policeman (with Chuck Berry)

Shiloh Fernandez

Phil Chess

Jill Flint

Shelly Feder

Erik Frandsen

Engineer - Present Day

Gano Grills

Slick Pimp

Suzette Gunn

Minnie Ripperton

Jordan Haynes

Pot Strong

William Hill

Policeman (with the Stones)

Mike Hodge

Bartender

Tyler Humphrey

Muddy - Age 6

Osas Ighodaro

Maid

Kevin Jackson

Mysterious Black Man

Albert Jones

Hubert Sumlin

Rayan Lawrence

Harmonica Player

Chyna Layne

Pot's Girlfriend Juanita

Kevin Mambo

Jimmy Rogers

Aaron Muñoz

Manager

Wade Mylius

Bouncer

Rebecca Pappa

Another Blonde

Q-Tip

Hip Hop Artist

Ginnie Randall

Muddy's Grandmother

Jake Robards

Producer - Present Day

Jay O. Sanders

Mr. Feder

Samuel Smith

Guitarist

Isiah Whitlock Jr.

Mississippi DJ

Lawrence P. Beron

Overseer (uncredited)

Vincent D'Onofrio

Mississippi DJ (uncredited)

Evan Hart

Young Lover (uncredited)

Andrew Kaempfer

Chicago Cop (uncredited)

Rege Lewis

Bystander (uncredited)

Malikha Mallette

Little Walter's Girlfriend (uncredited)

Adaku Ononogbo

Muddy Waters' Girlfriend (uncredited)