Bill Burr

Self

Keanu Reeves

Ted

Alex Winter

Bill

Club Soda Kenny

Self (uncredited)

Kristen Schaal

Kelly

Samara Weaving

Thea

Jack Haven

Billie

William Sadler

Death

Anthony Carrigan

Dennis Caleb McCoy

Erinn Hayes

Elizabeth

Jayma Mays

Joanna

Hal Landon Jr.

Chief Logan

Beck Bennett

Deacon

Kid Cudi

Kid Cudi

Amy Stoch

Missy

Holland Taylor

The Great Leader

Jillian Bell

Dr. Taylor Wood

Dave Grohl

Dave Grohl

DazMann Still

Jimi Hendrix

Jeremiah Craft

Louis Armstrong

Sharon Gee

Ling Lun

Patty Anne Miller

Grom

George Carlin

Rufus Hologram (archive footage)

Piotr Michael

Rufus (voice)

Shoshana Bean

First Noble

Sharon K. London

Second Noble

Al Vicente

Lead Scientist

Jared Bankens

Jesus / Young Ted

Ed Solomon

Stupid Demon

Chris Matheson

Ugly Demon

Kelly Carlin-McCall

Head Technician

Mickey Gooch Jr.

Clete

Billy Slaughter

Young Bill

Reece Loustalot

Babe Ruth

William E. Harris

George Washington

Kimberly Stockton

Queen Elizabeth

Chief Xian aTunde Adjuah

Noble

Bridget Andrews

Cleopatra

Artis Burney

Buddha

Gretchen Byers

Renaissance Lady

Georgia Cohran

Harriet Tubman

David Calloway

Roman Soldier

Ned Yousef

Gandhi

Alexis Long

Cavewoman

Alex Halpern

Scientist

Bill Prady

Scientist

Nicolas Bosc

Caveman (uncredited)

Daniel Dorr

Mozart (uncredited)

Gregory Hobson

Tough Prisoner (uncredited)

'Weird Al' Yankovic

Guy Playing Accordion (uncredited)

William Buster Benefield

Wedding Guest (uncredited)

Michael Biss

Umpire (uncredited)

Guillermo Rodriguez

Guy in Shower (uncredited)

Julia Holt

Tambourine Player (uncredited)